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California Environmental Protection Agency watch list

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STATE OF CALIFORNIA
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT
SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986
CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY
18-Dec-09
The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For easy reference, chemicals which are shown underlined are newly added. Chemicals or endpoints shown in strikeout were placed on the Proposition 65 list on the date noted, and have subsequently been removed. For those chemicals for which a no significant risk level (NSRL) for carcinogens or maximum allowable dose level (MADL) for reproductive toxicants has been adopted, it is denoted in the column, "NSRL or MADL."
Chemical Type of Toxicity CAS No. Date Listed NSRL or MADL (µg/day)a
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) cancer 26148-68-5 01-Jan-90 2
Acetaldehyde cancer 75-07-0 01-Apr-88 90 (inhalation)
Acetamide cancer 60-35-5 01-Jan-90 10
Acetazolamide developmental 59-66-5 20-Aug-99
Acetochlor cancer 34256-82-1 01-Jan-89
Acetohydroxamic acid developmental 546-88-3 01-Apr-90
2-Acetylaminofluorene cancer 53-96-3 01-Jul-87 0.2
Acifluorfen sodium cancer 62476-59-9 01-Jan-90
Acrylamide cancer 79-06-1 01-Jan-90 0.2
Acrylonitrile cancer 107-13-1 01-Jul-87 0.7
Actinomycin D cancer 50-76-0 01-Oct-89 0.00008
Actinomycin D developmental 50-76-0 01-Oct-92
AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide cancer 3688-53-7 01-Jul-87 3
Aflatoxins cancer --- 01-Jan-88
Alachlor cancer 15972-60-8 01-Jan-89
Alcoholic beverages, when associated with alcohol abuse cancer --- 01-Jul-88
Aldrin cancer 309-00-2 01-Jul-88 0.04
All-trans retinoic acid developmental 302-79-4 01-Jan-89
Allyl chloride Delisted October 29, 1999 cancer 107-05-1 01-Jan-90
Alprazolam developmental 28981-97-7 01-Jul-90
Altretamine developmental, male 645-05-6 20-Aug-99
Amantadine hydrochloride developmental 665-66-7 27-Feb-01
Amikacin sulfate developmental 39831-55-5 01-Jul-90
2-Aminoanthraquinone cancer 117-79-3 01-Oct-89 20
p-Aminoazobenzene cancer 60-09-3 01-Jan-90
o-Aminoazotoluene cancer 97-56-3 01-Jul-87 0.2
4-Aminobiphenyl (4-amino-diphenyl) cancer 92-67-1 27-Feb-87 0.03
1-Amino-2,4-dibromoanthraquinone cancer 81-49-2 26-Aug-97
3-Amino-9-ethylcarbazole hydrochloride cancer 6109-97-3 01-Jul-89 9
2-Aminofluorene cancer 153-78-6 29-Jan-99
Aminoglutethimide developmental 125-84-8 01-Jul-90
Aminoglycosides developmental --- 01-Oct-92
1-Amino-2-methylanthraquinone cancer 82-28-0 01-Oct-89 5
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole cancer 712-68-5 01-Jul-87 0.04
4-Amino-2-nitrophenol cancer 119-34-6 29-Jan-99
Aminopterin developmental, female 54-62-6 01-Jul-87
Amiodarone hydrochloride developmental, female, male 19774-82-4 26-Aug-97
Amitraz developmental 33089-61-1 30-Mar-99
Amitrole cancer 61-82-5 01-Jul-87 0.7
Amoxapine developmental 14028-44-5 15-May-98
Amsacrine cancer 51264-14-3 07-Aug-09
tert-Amyl methyl ether developmental 994-05-8 18-Dec-09
Anabolic steroids female, male --- 01-Apr-90
Analgesic mixtures containing Phenacetin cancer --- 27-Feb-87
Angiotensin converting enzyme (ACE) inhibitors developmental --- 01-Oct-92
Aniline cancer 62-53-3 01-Jan-90 100
Aniline hydrochloride cancer 142-04-1 15-May-98
o-Anisidine cancer 90-04-0 01-Jul-87 5
o-Anisidine hydrochloride cancer 134-29-2 01-Jul-87 7
Anisindione developmental 117-37-3 01-Oct-92
Antimony oxide (Antimony trioxide) cancer 1309-64-4 01-Oct-90
Anthraquinone cancer 84-65-1 28-Sep-07
Aramite cancer 140-57-8 01-Jul-87 20
Areca nut cancer --- 03-Feb-06
Aristolochic acids cancer --- 09-Jul-04
Arsenic (inorganic arsenic compounds) cancer -- 27-Feb-87 0.06 (inhalation) 10 (except inhalation)
Arsenic (inorganic oxides) developmental --- 01-May-97
Asbestos cancer 1332-21-4 27-Feb-87 100 fibers/day (inhalation)
Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) developmental, female 50-78-2 01-Jul-90
Atenolol developmental 29122-68-7 26-Aug-97
Auramine cancer 492-80-8 01-Jul-87 0.8
Auranofin developmental 34031-32-8 29-Jan-99
Azacitidine cancer 320-67-2 01-Jan-92
Azaserine cancer 115-02-6 01-Jul-87 0.06
Azathioprine cancer 446-86-6 27-Feb-87 0.4
Azathioprine developmental 446-86-6 01-Sep-96
Azobenzene cancer 103-33-3 01-Jan-90 6
Barbiturates developmental --- 01-Oct-92
Beclomethasone dipropionate developmental 5534-09-8 15-May-98
Benomyl developmental, male 17804-35-2 01-Jul-91
Benthiavalicarb-isopropyl cancer 177406-68-7 01-Jul-08
Benz[a]anthracene cancer 56-55-3 01-Jul-87 0.033 (oral)
Benzene cancer 71-43-2 27-Feb-87 6.4 (oral) 13 (inhalation)
Benzene developmental, male 71-43-2 26-Dec-97 24 (oral) 49 (inhalation)
Benzidine [and its salts] cancer 92-87-5 27-Feb-87 0.001
Benzidine-based dyes cancer --- 01-Oct-92
Benzodiazepines developmental --- 01-Oct-92
Benzo[b]fluoranthene cancer 205-99-2 01-Jul-87 0.096 (oral)
Benzo[j]fluoranthene cancer 205-82-3 01-Jul-87 0.11 (oral)
Benzo[k]fluoranthene cancer 207-08-9 01-Jul-87
Benzofuran cancer 271-89-6 01-Oct-90 1.1
Benzo[a]pyrene cancer 50-32-8 01-Jul-87 0.06
Benzotrichloride cancer 98-07-7 01-Jul-87
Benzphetamine hydrochloride developmental 5411-22-3 01-Apr-90
Benzyl chloride cancer 100-44-7 01-Jan-90 4
Benzyl violet 4B cancer 1694-09-3 01-Jul-87 30
Beryllium and beryllium compounds cancer --- 01-Oct-87
Beryllium 0.1
Beryllium oxide 0.1
Beryllium sulfate 0.0002
Betel quid with tobacco cancer --- 01-Jan-90
Betel quid without tobacco cancer --- 03-Feb-06
2,2-Bis(bromomethyl)-1,3-propanediol cancer 3296-90-0 01-May-96
Bis(2-chloroethyl)ether cancer 111-44-4 01-Apr-88 0.3
N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) cancer 494-03-1 27-Feb-87
Bischloroethyl nitrosourea (BCNU) (Carmustine) cancer 154-93-8 01-Jul-87
Bischloroethyl nitrosourea (BCNU) (Carmustine) developmental 154-93-8 01-Jul-90
Bis(chloromethyl)ether cancer 542-88-1 27-Feb-87 0.02
Bis(2-chloro-1-methylethyl)ether, technical grade cancer --- 29-Oct-99
Bitumens, extracts of steam-refined and air refined cancer --- 01-Jan-90
Bracken fern cancer --- 01-Jan-90
Bromacil lithium salt developmental 53404-19-6 18-May-99
Bromacil lithium salt male 53404-19-6 17-Jan-03
Bromate cancer 15541-45-4 31-May-02
Bromodichloromethane cancer 75-27-4 01-Jan-90 5
Bromoethane cancer 74-96-4 22-Dec-00
Bromoform cancer 75-25-2 01-Apr-91 64
1-Bromopropane developmental, female, male 106-94-5 07-Dec-04
2-Bromopropane female, male 75-26-3 31-May-05
Bromoxynil developmental 1689-84-5 01-Oct-90
Bromoxynil octanoate developmental 1689-99-2 18-May-99
Butabarbital sodium developmental 143-81-7 01-Oct-92
1,3-Butadiene cancer 106-99-0 01-Apr-88 0.4
1,3-Butadiene developmental, female, male 106-99-0 16-Apr-04
1,4-Butanediol dimethanesulfonate (Busulfan) cancer 55-98-1 27-Feb-87
1,4-Butanediol dimethanesulfonate (Busulfan) developmental 55-98-1 01-Jan-89
Butylated hydroxyanisole cancer 25013-16-5 01-Jan-90 4000
Butyl benzyl phthalate (BBP) developmental 85-68-7 02-Dec-05
n-Butyl glycidyl ether male 2426-08-6 07-Aug-09
beta-Butyrolactone cancer 3068-88-0 01-Jul-87 0.7
Cacodylic acid cancer 75-60-5 01-May-96
Cadmium developmental, male --- 01-May-97 4.1 (oral)
Cadmium and cadmium compounds cancer --- 01-Oct-87
Cadmium 0.05 (inhalation)
Caffeic acid cancer 331-39-5 01-Oct-94
Captafol cancer 2425-06-1 01-Oct-88 5
Captan cancer 133-06-2 01-Jan-90 300
Carbamazepine developmental 298-46-4 29-Jan-99
Carbaryl developmental, male 63-25-2 07-Aug-09
Carbazole cancer 86-74-8 01-May-96 4.1
Carbon black (airborne, unbound particles of respirable size) cancer 1333-86-4 21-Feb-03
Carbon disulfide developmental, female, male 75-15-0 01-Jul-89
Carbon monoxide developmental 630-08-0 01-Jul-89
Carbon tetrachloride cancer 56-23-5 01-Oct-87 5
Carbon-black extracts cancer --- 01-Jan-90
Carboplatin developmental 41575-94-4 01-Jul-90
N-Carboxymethyl-N-nitrosourea cancer 60391-92-6 25-Jan-02 0.7
Catechol cancer 120-80-9 15-Jul-03
Ceramic fibers (airborne particles of respirable size) cancer --- 01-Jul-90
Certain combined chemotherapy for lymphomas cancer --- 27-Feb-87
Chenodiol developmental 474-25-9 01-Apr-90
Chlorambucil cancer 305-03-3 27-Feb-87 0.002
Chlorambucil developmental 305-03-3 01-Jan-89
Chloramphenicol cancer 56-75-7 01-Oct-89
Chlorcyclizine hydrochloride developmental 1620-21-9 01-Jul-87
Chlordane cancer 57-74-9 01-Jul-88 0.5
Chlordecone (Kepone) cancer 143-50-0 01-Jan-88 0.04
Chlordecone (Kepone) developmental 143-50-0 01-Jan-89
Chlordiazepoxide developmental 58-25-3 01-Jan-92
Chlordiazepoxide hydrochloride developmental 438-41-5 01-Jan-92
Chlordimeform cancer 6164-98-3 01-Jan-89
Chlorendic acid cancer 115-28-6 01-Jul-89 8
Chlorinated paraffins (Average chain length, C12;approximately 60 percent chlorine by weight) cancer 108171-26-2 01-Jul-89 8
p-Chloroaniline cancer 106-47-8 01-Oct-94
p-Chloroaniline hydrochloride cancer 20265-96-7 15-May-98
Chlorodibromomethane Delisted October 29, 1999 cancer 124-48-1 01-Jan-90
Chloroethane (Ethyl chloride) cancer 75-00-3 01-Jul-90 150
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) cancer 13010-47-4 01-Jan-88
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) developmental 13010-47-4 01-Jul-90
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) cancer 13909-09-6 01-Oct-88
Chloroform cancer 67-66-3 01-Oct-87 20 (oral) 40 (inhalation)
Chloroform developmental 67-66-3 07-Aug-09
Chloromethyl methyl ether (technical grade) cancer 107-30-2 27-Feb-87 0.3
3-Chloro-2-methylpropene cancer 563-47-3 01-Jul-89 5
1-Chloro-4-nitrobenzene cancer 100-00-5 29-Oct-99
4-Chloro-o-phenylenediamine cancer 95-83-0 01-Jan-88 40
Chloroprene cancer 126-99-8 02-Jun-00
2-Chloropropionic acid male 598-78-7 07-Aug-09
Chlorothalonil cancer 1897-45-6 01-Jan-89 200
p-Chloro-o-toluidine cancer 95-69-2 01-Jan-90 3
p-Chloro-o-toluidine, strong acid salts of cancer --- 15-May-98
p-Chloro-o-toluidine, hydrochloride 3.3
5-Chloro-o-toluidine and its strong acid salts cancer --- 24-Oct-97
Chlorotrianisene cancer 569-57-3 01-Sep-96
Chlorozotocin cancer 54749-90-5 01-Jan-92 0.003
Chlorsulfuron developmental, female, male 64902-72-3 14-May-99
Chromium (hexavalent compounds) cancer --- 27-Feb-87 0.001 (inhalation)
Chromium (hexavalent compounds) developmental, female, male --- 19-Dec-08
Chrysene cancer 218-01-9 01-Jan-90 0.35 (oral)
C.I. Acid Red 114 cancer 6459-94-5 01-Jul-92
C.I. Basic Red 9 monohydrochloride cancer 569-61-9 01-Jul-89 3
C.I. Direct Blue 15 cancer 2429-74-5 26-Aug-97
C.I. Direct Blue 218 cancer 28407-37-6 26-Aug-97 50
C.I. Solvent Yellow 14 cancer 842-07-9 15-May-98
Ciclosporin (Cyclosporin A; Cyclosporine) cancer 59865-13-3; 79217-60-0 01-Jan-92
Cidofovir cancer, developmental, female, male 113852-37-2 29-Jan-99
Cinnamyl anthranilate cancer 87-29-6 01-Jul-89 200
Cisplatin cancer 15663-27-1 01-Oct-88
Citrus Red No. 2 cancer 6358-53-8 01-Oct-89
Cladribine developmental 4291-63-8 01-Sep-96
Clarithromycin developmental 81103-11-9 01-May-97
Clobetasol propionate developmental, female 25122-46-7 15-May-98
Clofibrate cancer 637-07-0 01-Sep-96
Clomiphene citrate developmental 50-41-9 01-Apr-90
Clorazepate dipotassium developmental 57109-90-7 01-Oct-92
Cobalt metal powder cancer 7440-48-4 01-Jul-92
Cobalt [II] oxide cancer 1307-96-6 01-Jul-92
Cobalt sulfate cancer 10124-43-3 20-May-05
Cobalt sulfate heptahydrate cancer 10026-24-1 02-Jun-00
Cocaine developmental, female 50-36-2 01-Jul-89
Codeine phosphate developmental 52-28-8 15-May-98
Coke oven emissions cancer --- 27-Feb-87 0.3
Colchicine developmental, male 64-86-8 01-Oct-92
Conjugated estrogens cancer --- 27-Feb-87
Conjugated estrogens developmental --- 01-Apr-90
Creosotes cancer --- 01-Oct-88
p-Cresidine cancer 120-71-8 01-Jan-88 5
Cupferron cancer 135-20-6 01-Jan-88 3
Cyanazine developmental 21725-46-2 01-Apr-90
Cycasin cancer 14901-08-7 01-Jan-88
Cycloate developmental 1134-23-2 19-Mar-99
Cyclohexanol Delisted January 25, 2002 male 108-93-0 06-Nov-98
Cycloheximide developmental 66-81-9 01-Jan-89
Cyclophosphamide (anhydrous) cancer 50-18-0 27-Feb-87 1
Cyclophosphamide (anhydrous) developmental, female, male 50-18-0 01-Jan-89
Cyclophosphamide (hydrated) cancer 6055-19-2 27-Feb-87 1
Cyclophosphamide (hydrated) developmental, female, male 6055-19-2 01-Jan-89
Cyhexatin developmental 13121-70-5 01-Jan-89
Cytarabine developmental 147-94-4 01-Jan-89
Cytembena cancer 21739-91-3 15-May-98
D&C Orange No. 17 cancer 3468-63-1 01-Jul-90
D&C Red No. 8 cancer 2092-56-0 01-Oct-90
D&C Red No. 9 cancer 5160-02-1 01-Jul-90 100
D&C Red No. 19 cancer 81-88-9 01-Jul-90
Dacarbazine cancer 4342-03-4 01-Jan-88 0.01
Dacarbazine developmental 4342-03-4 29-Jan-99
Daminozide cancer 1596-84-5 01-Jan-90 40
Danazol developmental 17230-88-5 01-Apr-90
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) cancer 117-10-2 01-Jan-92 9
Daunomycin cancer 20830-81-3 01-Jan-88
Daunorubicin hydrochloride developmental 23541-50-6 01-Jul-90
2,4-D butyric acid developmental, male 94-82-6 18-Jun-99 910
DDD (Dichlorodiphenyl-dichloroethane) cancer 72-54-8 01-Jan-89 2 (DDT, DDE, DDD in combination)
DDE (Dichlorodiphenyl-dichloroethylene) cancer 72-55-9 01-Jan-89 2 (DDT, DDE, DDD in combination)
DDT (Dichlorodiphenyl-trichloroethane) cancer 50-29-3 01-Oct-87 2 (DDT, DDE, DDD in combination)
o,p'-DDT developmental, female, male 789-02-6 15-May-98
p,p'-DDT developmental, female, male 50-29-3 15-May-98
DDVP (Dichlorvos) cancer 62-73-7 01-Jan-89 2
2,4-DP (dichloroprop) Delisted January 25, 2002 developmental 120-36-5 27-Apr-99
N,N'-Diacetylbenzidine cancer 613-35-4 01-Oct-89
2,4-Diaminoanisole cancer 615-05-4 01-Oct-90 30
2,4-Diaminoanisole sulfate cancer 39156-41-7 01-Jan-88 50
4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) cancer 101-80-4 01-Jan-88 5
2,4-Diaminotoluene cancer 95-80-7 01-Jan-88 0.2
Demeclocycline hydrochloride (internal use) developmental 64-73-3 01-Jan-92
Diaminotoluene (mixed) cancer --- 01-Jan-90
Diazepam developmental 439-14-5 01-Jan-92
Diazoaminobenzene cancer 136-35-6 20-May-05
Diazoxide developmental 364-98-7 27-Feb-01
Dibenz[a,h]acridine cancer 226-36-8 01-Jan-88
Dibenz[a,j]acridine cancer 224-42-0 01-Jan-88
Dibenz[a,h]anthracene cancer 53-70-3 01-Jan-88 0.2
7H-Dibenzo[c,g]carbazole cancer 194-59-2 01-Jan-88 0.0030 (oral)
Dibenzo[a,e]pyrene cancer 192-65-4 01-Jan-88
Dibenzo[a,h]pyrene cancer 189-64-0 01-Jan-88 0.0054 (oral)
Dibenzo[a,i]pyrene cancer 189-55-9 01-Jan-88 0.0050 (oral)
Dibenzo[a,l]pyrene cancer 191-30-0 01-Jan-88
Dibromoacetic acid cancer 631-64-1 17-Jun-08
1,2-Dibromo-3-chloropropane (DBCP) cancer 96-12-8 01-Jul-87 0.1
1,2-Dibromo-3-chloropropane (DBCP) male 96-12-8 27-Feb-87 3.1 (oral) 4.3 (inhalation)
2,3-Dibromo-1-propanol cancer 96-13-9 01-Oct-94
Dichloroacetic acid cancer 79-43-6 01-May-96
Dichloroacetic acid male 79-43-6 07-Aug-09
p-Dichlorobenzene cancer 106-46-7 01-Jan-89 20
3,3'-Dichlorobenzidine cancer 91-94-1 01-Oct-87 0.6
3,3'-Dichlorobenzidine dihydrochloride cancer 612-83-9 15-May-98
1,4-Dichloro-2-butene cancer 764-41-0 01-Jan-90
3,3'-Dichloro-4,4'-diamino-diphenyl ether cancer 28434-86-8 01-Jan-88
1,1-Dichloroethane cancer 75-34-3 01-Jan-90 100
Dichloromethane (Methylene chloride) cancer 75-09-2 01-Apr-88 50 200 (inhalation)
Dichlorophene developmental 97-23-4 27-Apr-99
Dichlorphenamide developmental 120-97-8 27-Feb-01
Diclofop methyl developmental 51338-27-3 05-Mar-99
1,2-Dichloropropane cancer 78-87-5 01-Jan-90 9.7
1,3-Dichloropropene cancer 542-75-6 01-Jan-89
Dicumarol developmental 66-76-2 01-Oct-92
Dieldrin cancer 60-57-1 01-Jul-88 0.04
Dienestrol cancer 84-17-3 01-Jan-90
Diepoxybutane cancer 1464-53-5 01-Jan-88
Diesel engine exhaust cancer --- 01-Oct-90
Di-n-butyl phthalate (DBP) developmental, female, male 84-74-2 02-Dec-05 8.7
Di(2-ethylhexyl)phthalate cancer 117-81-7 01-Jan-88 310
Di(2-ethylhexyl)phthalate developmental, male 117-81-7 24-Oct-03 For intravenous exposure: 4200 (adults) 600 (infant boys, age 29 days- 24 mos.) 210 (neonatal infant boys, age 0-28 days). For oral exposure: 410 (adults) 58 (infant boys, age 29 days- 24 mos.) 20 (neonatal infant boys, age 0-28 days). [Levels for male children and adolescents can be calculated by application of the default bodyweights specfied in Section 12703(a)(8) to the procedure specified in Sections 12801 and 12803.]
Di-n-hexyl phthalate (DnHP) female, male 84-75-3 02-Dec-05
1,2-Diethylhydrazine cancer 1615-80-1 01-Jan-88
Diethylstilbestrol (DES) cancer 56-53-1 27-Feb-87 0.002
Diethylstilbestrol (DES) developmental 56-53-1 01-Jul-87
Diethyl sulfate cancer 64-67-5 01-Jan-88
Diflunisal developmental, female 22494-42-4 29-Jan-99
Diglycidyl ether male 2238-07-5 07-Aug-09
Diglycidyl resorcinol ether (DGRE) cancer 101-90-6 01-Jul-89 0.4
Dihydroergotamine mesylate developmental 6190-39-2 01-May-97
Dihydrosafrole cancer 94-58-6 01-Jan-88 20
Diisopropyl sulfate cancer 2973-10-6 01-Apr-93
Di-isodecyl phthalate (DIDP) developmental 68515-49-1/ 26761-40-0 20-Apr-07
Diltiazem hydrochloride developmental 33286-22-5 27-Feb-01
3,3'-Dimethoxybenzidine (o-Dianisidine) cancer 119-90-4 01-Jan-88 0.15
3,3'-Dimethoxybenzidine dihydrochloride cancer 20325-40-0 01-Oct-90 0.19
3,3'-Dimethoxybenzidine-based dyes metabolized to 3,3'-dimethoxybenzidine cancer --- 11-Jun-04
4-Dimethylaminoazobenzene cancer 60-11-7 01-Jan-88 0.2
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole cancer 55738-54-0 01-Jan-88 2
7,12-Dimethylbenz(a)anthracene cancer 57-97-6 01-Jan-90 0.003
3,3'-Dimethylbenzidine (ortho-Tolidine) cancer 119-93-7 01-Jan-88 0.044
3,3'-Dimethylbenzidine dihydrochloride cancer 612-82-8 01-Apr-92 0.059
3,3'-Dimethylbenzidine-based dyes metabolized to 3,3'-dimethylbenzidine cancer --- 11-Jun-04
Dimethylcarbamoyl chloride cancer 79-44-7 01-Jan-88 0.05
1,1-Dimethylhydrazine (UDMH) cancer 57-14-7 01-Oct-89
1,2-Dimethylhydrazine cancer 540-73-8 01-Jan-88 0.001
Dimethyl sulfate cancer 77-78-1 01-Jan-88
Dimethylvinylchloride cancer 513-37-1 01-Jul-89 20
m-Dinitrobenzene male 99-65-0 01-Jul-90 38
o-Dinitrobenzene male 528-29-0 01-Jul-90
p-Dinitrobenzene male 100-25-4 01-Jul-90
3,7-Dinitrofluoranthene cancer 105735-71-5 26-Aug-97
3,9-Dinitrofluoranthene cancer 22506-53-2 26-Aug-97
1,6-Dinitropyrene cancer 42397-64-8 01-Oct-90
1,8-Dinitropyrene cancer 42397-65-9 01-Oct-90
Dinitrotoluene (technical grade) female, male --- 20-Aug-99
Dinitrotoluene mixture, 2,4-/2,6- cancer --- 01-May-96
2,4-Dinitrotoluene cancer 121-14-2 01-Jul-88 2
2,4-Dinitrotoluene male 121-14-2 20-Aug-99
2,6-Dinitrotoluene cancer 606-20-2 01-Jul-95
2,6-Dinitrotoluene male 606-20-2 20-Aug-99
Dinocap developmental 39300-45-3 01-Apr-90
Dinoseb developmental, male 88-85-7 01-Jan-89
1,4-Dioxane cancer 123-91-1 01-Jan-88 30
Diphenylhydantoin (Phenytoin) cancer 57-41-0 01-Jan-88
Diphenylhydantoin (Phenytoin) developmental 57-41-0 01-Jul-87
Diphenylhydantoin (Phenytoin), sodium salt cancer 630-93-3 01-Jan-88
Di-n-propyl isocinchomeronate (MGK Repellent 326) cancer 136-45-8 01-May-96
Direct Black 38 (technical grade) cancer 1937-37-7 01-Jan-88 0.09
Direct Blue 6 (technical grade) cancer 2602-46-2 01-Jan-88 0.09
Direct Brown 95 (technical grade) cancer 16071-86-6 01-Oct-88 0.1
Disodium cyanodithioimidocarbonate developmental 138-93-2 30-Mar-99 56 (oral) 170 (oral) as 32% pesticidal formulation
Disperse Blue 1 cancer 2475-45-8 01-Oct-90 200
Diuron cancer 330-54-1 31-May-02
Doxorubicin hydrochloride (Adriamycin) cancer 25316-40-9 01-Jul-87
Doxorubicin hydrochloride (Adriamycin) developmental, male 25316-40-9 29-Jan-99
Doxycycline (internal use) developmental 564-25-0 01-Jul-90
Doxycycline calcium (internal use) developmental 94088-85-4 01-Jan-92
Doxycycline hyclate (internal use) developmental 24390-14-5 01-Oct-91
Doxycycline monohydrate (internal use) developmental 17086-28-1 01-Oct-91
Endrin developmental 72-20-8 15-May-98
Environmental tobacco smoke (ETS) developmental --- 09-Jun-06
Epichlorohydrin cancer 106-89-8 01-Oct-87 9
Epichlorohydrin male 106-89-8 01-Sep-96
Ergotamine tartrate developmental 379-79-3 01-Apr-90
Erionite cancer 12510-42-8; 66733-21-9 01-Oct-88
Estradiol 17B cancer 50-28-2 01-Jan-88 0.02
Estragole cancer 140-67-0 29-Oct-99
Estrogens, steroidal cancer --- 19-Aug-05
Estrone cancer 53-16-7 01-Jan-88
Estropipate cancer, developmental 7280-37-7 26-Aug-97
Ethinylestradiol cancer 57-63-6 01-Jan-88
Ethionamide developmental 536-33-4 26-Aug-97
Ethoprop cancer 13194-48-4 27-Feb-01
Ethyl acrylate cancer 140-88-5 01-Jul-89
Ethyl alcohol in alcoholic beverages developmental --- 01-Oct-87
Ethylbenzene cancer 100-41-4 11-Jun-04 54 (inhalation) 41 (oral)
Ethyl-tert-butyl ether male 637-92-3 18-Dec-09
Ethyl dipropylthiocarbamate developmental 759-94-4 27-Apr-99 700 (oral and inhalation) 6700 (dermal)
Ethyl-4,4'-dichlorobenzilate cancer 510-15-6 01-Jan-90 7
Ethylene dibromide cancer 106-93-4 01-Jul-87 0.2 (oral) 3 (inhalation)
Ethylene dibromide developmental, male 106-93-4 15-May-98
Ethylene dichloride (1,2-Dichloroethane) cancer 107-06-2 01-Oct-87 10
Ethylene glycol monoethyl ether developmental, male 110-80-5 01-Jan-89 750 (oral) 960 (inhalation)
Ethylene glycol monoethyl ether acetate developmental, male 111-15-9 01-Jan-93 1100 (oral) 1400 (inhalation)
Ethylene glycol monomethyl ether developmental, male 109-86-4 01-Jan-89 63 (oral)
Ethylene glycol monomethyl ether acetate developmental, male 110-49-6 01-Jan-93 98 (oral)
Ethyleneimine cancer 151-56-4 01-Jan-88 0.01
Ethylene oxide cancer 75-21-8 01-Jul-87 2
Ethylene oxide female 75-21-8 27-Feb-87 20
Ethylene oxide developmental, male 75-21-8 07-Aug-09
Ethylene thiourea cancer 96-45-7 01-Jan-88 20
Ethylene thiourea developmental 96-45-7 01-Jan-93
2-Ethylhexanoic acid developmental 149-57-5 07-Aug-09
Ethyl methanesulfonate cancer 62-50-0 01-Jan-88
Etodolac developmental, female 41340-25-4 20-Aug-99
Etoposide developmental 33419-42-0 01-Jul-90
Etretinate developmental 54350-48-0 01-Jul-87
Fenoxaprop ethyl developmental 66441-23-4 26-Mar-99
Fenoxycarb cancer 72490-01-8 02-Jun-00
Filgrastim developmental 121181-53-1 27-Feb-01
Fluazifop butyl developmental 69806-50-4 06-Nov-98
Flunisolide developmental, female 3385-03-3 15-May-98
Fluorouracil developmental 51-21-8 01-Jan-89
Fluoxymesterone developmental 76-43-7 01-Apr-90
Flurazepam hydrochloride developmental 1172-18-5 01-Oct-92
Flurbiprofen developmental, female 5104-49-4 20-Aug-99
Flutamide developmental 13311-84-7 01-Jul-90
Fluticasone propionate developmental 80474-14-2 15-May-98
Fluvalinate developmental 69409-94-5 06-Nov-98
Folpet cancer 133-07-3 01-Jan-89 200
Formaldehyde (gas) cancer 50-00-0 01-Jan-88 40
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole cancer 3570-75-0 01-Jan-88 0.3
Fumonisin B1 cancer 116355-83-0 14-Nov-03
Furan cancer 110-00-9 01-Oct-93
Furazolidone cancer 67-45-8 01-Jan-90
Furmecyclox cancer 60568-05-0 01-Jan-90 20
Fusarin C cancer 79748-81-5 01-Jul-95
Gallium arsenide cancer 1303-00-0 01-Aug-08
Ganciclovir cancer, developmental, male 82410-32-0 26-Aug-97
Ganciclovir sodium developmental, male 107910-75-8 26-Aug-97
Gasoline engine exhaust (condensates/extracts) cancer --- 01-Oct-90
Gemfibrozil cancer 25812-30-0 22-Dec-00
Gemfibrozil female, male 25812-30-0 20-Aug-99
Glasswool fibers (airborne particles of respirable size) cancer --- 01-Jul-90
Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3',2'-d]imidazole) cancer 67730-11-4 01-Jan-90 0.1
Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) cancer 67730-10-3 01-Jan-90 0.5
Glycidaldehyde cancer 765-34-4 01-Jan-88
Glycidol cancer 556-52-5 01-Jul-90
Goserelin acetate developmental, female, male 65807-02-5 26-Aug-97
Griseofulvin cancer 126-07-8 01-Jan-90
Gyromitrin (Acetaldehyde methylformylhydrazone) cancer 16568-02-8 01-Jan-88 0.07
Halazepam developmental 23092-17-3 01-Jul-90
Halobetasol propionate developmental 66852-54-8 20-Aug-99
Haloperidol developmental, female 52-86-8 29-Jan-99
Halothane developmental 151-67-7 01-Sep-96
HC Blue 1 cancer 2784-94-3 01-Jul-89 10
Heptachlor cancer 76-44-8 01-Jul-88 0.2
Heptachlor developmental 76-44-8 20-Aug-99
Heptachlor epoxide cancer 1024-57-3 01-Jul-88 0.08
Herbal remedies containing plant species of the genus Aristolochia cancer --- 09-Jul-04
Hexachlorobenzene cancer 118-74-1 01-Oct-87 0.4
Hexachlorobenzene developmental 118-74-1 01-Jan-89
Hexachlorocyclohexane (technical grade) cancer --- 01-Oct-87 0.2
Hexachlorocyclohexane (alpha isomer) 0.3
Hexachlorocyclohexane (beta isomer) 0.5
Hexachlorocyclohexane (gamma isomer) 0.6
Hexachlorodibenzodioxin cancer 34465-46- 8 01-Apr-88 0.0002
Hexachloroethane cancer 67-72-1 01-Jul-90 20
2,4-Hexadienal (89% trans, trans isomer; 11% cis, trans isomer) cancer --- 04-Mar-05
Hexafluoroacetone male 684-16-2 01-Aug-08
Hexamethylphosphoramide cancer 680-31-9 01-Jan-88
Hexamethylphosphoramide male 680-31-9 01-Oct-94
Histrelin acetate developmental --- 15-May-98
Hydramethylnon developmental, male 67485-29-4 05-Mar-99 120 (oral)
Hydrazine cancer 302-01-2 01-Jan-88 0.04
Hydrazine sulfate cancer 10034-93-2 01-Jan-88 0.2
Hydrazobenzene (1,2-Diphenylhydrazine) cancer 122-66-7 01-Jan-88 0.8
1-Hydroxyanthraquinone cancer 129-43-1 27-May-05
Hydroxyurea developmental 127-07-1 01-May-97
Idarubicin hydrochloride developmental, male 57852-57-0 20-Aug-99
Ifosfamide developmental 3778-73-2 01-Jul-90
Iodine-131 developmental 10043-66-0 01-Jan-89
Indeno [1,2,3-cd]pyrene cancer 193-39-5 01-Jan-88
Indium phosphide cancer 22398-80-7 27-Feb-01
IQ (2-Amino-3-methylimidazo[4,5-f] quinoline) cancer 76180-96-6 01-Apr-90 0.5
Iprodione cancer 36734-19-7 01-May-96
Iprovalicarb cancer 140923-17-7 & 140923-25-7 01-Jun-07
Iron dextran complex cancer 9004-66-4 01-Jan-88
Isobutyl nitrite cancer 542-56-3 01-May-96 7.4
Isoprene cancer 78-79-5 01-May-96
Isosafrole Delisted December 8, 2006 cancer 120-58-1 01-Oct-89
Isotretinoin developmental 4759-48-2 01-Jul-87
Isoxaflutole cancer 141112-29-0 22-Dec-00
Lactofen cancer 77501-63-4 01-Jan-89
Lasiocarpine cancer 303-34-4 01-Apr-88 0.09
Lead developmental, female, male --- 27-Feb-87 0.5
Lead and lead compounds cancer --- 01-Oct-92
Lead 15 (oral)
Lead acetate cancer 301-04-2 01-Jan-88 23 (oral)
Lead phosphate cancer 7446-27-7 01-Apr-88 58 (oral)
Lead subacetate cancer 1335-32-6 01-Oct-89 41 (oral)
Leuprolide acetate developmental, female, male 74381-53-6 26-Aug-97
Levodopa developmental 59-92-7 29-Jan-99
Levonorgestrel implants female 797-63-7 15-May-98
Lindane and other hexachlorocyclohexane isomers cancer --- 01-Oct-89
Linuron developmental 330-55-2 19-Mar-99 460
Lithium carbonate developmental 554-13-2 01-Jan-91
Lithium citrate developmental 919-16-4 01-Jan-91
Lorazepam developmental 846-49-1 01-Jul-90
Lovastatin developmental 75330-75-5 01-Oct-92
Lynestrenol cancer 52-76-6 27-Feb-01
Mancozeb cancer 8018-01-7 01-Jan-90
Maneb cancer 12427-38-2 01-Jan-90
Marijuana smoke cancer --- 19-Jun-09
Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) cancer 68006-83-7 01-Jan-90 0.6
Mebendazole developmental 31431-39-7 20-Aug-99
Medroxyprogesterone acetate cancer 71-58-9 01-Jan-90
Medroxyprogesterone acetate developmental 71-58-9 01-Apr-90
Megestrol acetate developmental 595-33-5 01-Jan-91
MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) cancer 77094-11-2 01-Oct-94 0.46
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) cancer 77500-04-0 01-Oct-94 0.41
Melphalan cancer 148-82-3 27-Feb-87 0.005
Melphalan developmental 148-82-3 01-Jul-90
Menotropins developmental 9002-68-0 01-Apr-90
Mepanipyrim cancer 110235-47-7 01-Jul-08
Meprobamate developmental 57-53-4 01-Jan-92
Mercaptopurine developmental 6112-76-1 01-Jul-90
Mercury and mercury compounds developmental --- 01-Jul-90
Merphalan cancer 531-76-0 01-Apr-88
Mestranol cancer 72-33-3 01-Apr-88
Methacycline hydrochloride developmental 3963-95-9 01-Jan-91
Metham sodium cancer 137-42-8 06-Nov-98
Metham sodium developmental 137-42-8 15-May-98
Methazole developmental 20354-26-1 01-Dec-99
Methimazole developmental 60-56-0 01-Jul-90
Methotrexate developmental 59-05-2 01-Jan-89
Methotrexate sodium developmental 15475-56-6 01-Apr-90
5-Methoxypsoralen with ultraviolet A therapy cancer 484-20-8 01-Oct-88
8-Methoxypsoralen with ultraviolet A therapy cancer 298-81-7 27-Feb-87
2-Methylaziridine (Propyleneimine) cancer 75-55-8 01-Jan-88 0.028
Methylazoxymethanol cancer 590-96-5 01-Apr-88
Methylazoxymethanol acetate cancer 592-62-1 01-Apr-88
Methyl bromide, as a structural fumigant developmental 74-83-9 01-Jan-93 810 (inhalation)
Methyl carbamate cancer 598-55-0 15-May-98 160
Methyl chloride developmental 74-87-3 10-Mar-00
Methyl chloride male 74-87-3 07-Aug-09
3-Methylcholanthrene cancer 56-49-5 01-Jan-90 0.03
5-Methylchrysene cancer 3697-24-3 01-Apr-88 0.0084 (oral)
4,4'-Methylene bis(2-chloroaniline) cancer 101-14-4 01-Jul-87 0.5
4,4'-Methylene bis(N,N-dimethyl)benzenamine cancer 101-61-1 01-Oct-89 20
4,4'-Methylene bis(2-methylaniline) cancer 838-88-0 01-Apr-88 0.8
4,4'-Methylenedianiline cancer 101-77-9 01-Jan-88 0.4
4,4'-Methylenedianiline dihydrochloride cancer 13552-44-8 01-Jan-88 0.6
Methyleugenol cancer 93-15-2 16-Nov-01
Methylhydrazine and its salts cancer --- 01-Jul-92
Methylhydrazine 0.058 (oral) 0.090 (inhalation)
Methylhydrazine sulfate 0.18
Methyl iodide cancer 74-88-4 01-Apr-88
Methyl mercury developmental --- 01-Jul-87
Methylmercury compounds cancer --- 01-May-96
Methyl methanesulfonate cancer 66-27-3 01-Apr-88 7
Methyl n-butyl ketone male 591-78-6 07-Aug-09
2-Methyl-1-nitroanthraquinone (of uncertain purity) cancer 129-15-7 01-Apr-88 0.2
N-Methyl-N'-nitro-N-nitrosoguanidine cancer 70-25-7 01-Apr-88 0.08
N-Methylolacrylamide cancer 924-42-5 01-Jul-90
N-Methylpyrrolidone developmental 872-50-4 15-Jun-01 3200 (inhalation) 17000 (dermal)
Methyltestosterone developmental 58-18-4 01-Apr-90
Methylthiouracil cancer 56-04-2 01-Oct-89 2
Metiram cancer 9006-42-2 01-Jan-90
Metiram developmental 9006-42-2 30-Mar-99
Metronidazole cancer 443-48-1 01-Jan-88
Michler's ketone cancer 90-94-8 01-Jan-88 0.8
Midazolam hydrochloride developmental 59467-96-8 01-Jul-90
Minocycline hydrochloride (internal use) developmental 13614-98-7 01-Jan-92
Mirex cancer 2385-85-5 01-Jan-88 0.04
Misoprostol developmental 59122-46-2 01-Apr-90
Mitomycin C cancer 50-07-7 01-Apr-88 0.00009
Mitoxantrone hydrochloride developmental 70476-82-3 01-Jul-90
Molinate developmental, female, male 2212-67-1 11-Dec-09
Monocrotaline cancer 315-22-0 01-Apr-88 0.07
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone cancer 139-91-3 01-Apr-88 0.18
Mustard Gas cancer 505-60-2 27-Feb-87
MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone) cancer 77439-76-0 22-Dec-00 0.11
Myclobutanil developmental, male 88671-89-0 16-Apr-99
Nabam developmental 142-59-6 30-Mar-99
Nafarelin acetate developmental 86220-42-0 01-Apr-90
Nafenopin cancer 3771-19-5 01-Apr-88
Nalidixic acid cancer 389-08-2 15-May-98 28
Naphthalene cancer 91-20-3 19-Apr-02 5.8
1-Naphthylamine cancer 134-32-7 01-Oct-89
2-Naphthylamine cancer 91-59-8 27-Feb-87 0.4
Neomycin sulfate (internal use) developmental 1405-10-3 01-Oct-92
Netilmicin sulfate developmental 56391-57-2 01-Jul-90
Nickel (Metallic) cancer 7440-02-0 01-Oct-89
Nickel acetate cancer 373-02-4 01-Oct-89
Nickel carbonate cancer 3333-67-3 01-Oct-89
Nickel carbonyl cancer 13463-39-3 01-Oct-87
Nickel carbonyl developmental 13463-39-3 01-Sep-96
Nickel compounds cancer --- 07-May-04
Nickel hydroxide cancer 12054-48-7; 12125-56-3 01-Oct-89
Nickelocene cancer 1271-28-9 01-Oct-89
Nickel oxide cancer 1313-99-1 01-Oct-89
Nickel refinery dust from the pyrometallurgical process cancer --- 01-Oct-87 0.8
Nickel subsulfide cancer 12035-72-2 01-Oct-87 0.4
Nicotine developmental 54-11-5 01-Apr-90
Nifedipine developmental, female, male 21829-25-4 29-Jan-99
Nimodipine developmental 66085-59-4 24-Apr-01
Niridazole cancer 61-57-4 01-Apr-88
Nitrapyrin cancer 1929-82-4 05-Oct-05
Nitrapyrin developmental 1929-82-4 30-Mar-99
Nitrilotriacetic acid cancer 139-13-9 01-Jan-88 100
Nitrilotriacetic acid, trisodium salt monohydrate cancer 18662-53-8 01-Apr-89 70
5-Nitroacenaphthene cancer 602-87-9 01-Apr-88 6
5-Nitro-o-anisidine Delisted December 8, 2006 cancer 99-59-2 01-Oct-89 10
o-Nitroanisole cancer 91-23-6 01-Oct-92
Nitrobenzene cancer 98-95-3 26-Aug-97
4-Nitrobiphenyl cancer 92-93-3 01-Apr-88
6-Nitrochrysene cancer 7496-02-8 01-Oct-90
Nitrofen (technical grade) cancer 1836-75-5 01-Jan-88 9
2-Nitrofluorene cancer 607-57-8 01-Oct-90
Nitrofurantoin male 67-20-9 01-Apr-91
Nitrofurazone cancer 59-87-0 01-Jan-90 0.5
1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone cancer 555-84-0 01-Apr-88 0.4
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide cancer 531-82-8 01-Apr-88 0.5
Nitrogen mustard (Mechlorethamine) cancer 51-75-2 01-Jan-88
Nitrogen mustard (Mechlorethamine) developmental 51-75-2 01-Jan-89
Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) cancer 55-86-7 01-Apr-88
Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) developmental 55-86-7 01-Jul-90
Nitrogen mustard N-oxide cancer 126-85-2 01-Apr-88
Nitrogen mustard N-oxide hydrochloride cancer 302-70-5 01-Apr-88
Nitromethane cancer 75-52-5 01-May-97 39
2-Nitropropane cancer 79-46-9 01-Jan-88
1-Nitropyrene cancer 5522-43-0 01-Oct-90
4-Nitropyrene cancer 57835-92-4 01-Oct-90
N-Nitrosodi-n-butylamine cancer 924-16-3 01-Oct-87 0.06
N-Nitrosodiethanolamine cancer 1116-54-7 01-Jan-88 0.3
N-Nitrosodiethylamine cancer 55-18-5 01-Oct-87 0.02
N-Nitrosodimethylamine cancer 62-75-9 01-Oct-87 0.04
p-Nitrosodiphenylamine cancer 156-10-5 01-Jan-88 30
N-Nitrosodiphenylamine cancer 86-30-6 01-Apr-88 80
N-Nitrosodi-n-propylamine cancer 621-64-7 01-Jan-88 0.1
N-Nitroso-N-ethylurea cancer 759-73-9 01-Oct-87 0.03
3-(N-Nitrosomethylamino) propionitrile cancer 60153-49-3 01-Apr-90
4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone cancer 64091-91-4 01-Apr-90 0.014
N-Nitrosomethylethylamine cancer 10595-95-6 01-Oct-89 0.03
N-Nitroso-N-methylurea cancer 684-93-5 01-Oct-87 0.006
N-Nitroso-N-methylurethane cancer 615-53-2 01-Apr-88 0.006
N-Nitrosomethylvinylamine cancer 4549-40-0 01-Jan-88
N-Nitrosomorpholine cancer 59-89-2 01-Jan-88 0.1
N-Nitrosonornicotine cancer 16543-55-8 01-Jan-88 0.5
N-Nitrosopiperidine cancer 100-75-4 01-Jan-88 0.07
N-Nitrosopyrrolidine cancer 930-55-2 01-Oct-87 0.3
N-Nitrososarcosine cancer 13256-22-9 01-Jan-88
o-Nitrotoluene cancer 88-72-2 15-May-98
Nitrous oxide developmental 10024-97-2 01-Aug-08
Norethisterone (Norethindrone) cancer 68-22-4 01-Oct-89
Norethisterone (Norethindrone) developmental 68-22-4 01-Apr-90
Norethisterone acetate (Norethindrone acetate) developmental 51-98-9 01-Oct-91
Norethisterone (Norethindrone) /Ethinyl estradiol developmental 68-22-4 57-63-6 01-Apr-90
Norethisterone (Norethindrone) /Mestranol developmental 68-22-4 72-33-3 01-Apr-90
Norethynodrel cancer 68-23-5 27-Feb-01
Norgestrel developmental 6533-00-2 01-Apr-90
Ochratoxin A cancer 303-47-9 01-Jul-90
Oil Orange SS cancer 2646-17-5 01-Apr-88
Oral contraceptives, combined cancer --- 01-Oct-89
Oral contraceptives, sequential cancer --- 01-Oct-89
Oryzalin cancer 19044-88-3 12-Sep-08
Oxadiazon cancer 19666-30-9 01-Jul-91
Oxadiazon developmental 19666-30-9 15-May-98
Oxazepam cancer 604-75-1 01-Oct-94
Oxazepam developmental 604-75-1 01-Oct-92
p,p'-Oxybis(benzenesulfonyl hydrazide) developmental 80-51-3 07-Aug-09
Oxydemeton methyl female, male 301-12-2 06-Nov-98
Oxymetholone cancer 434-07-1 01-Jan-88
Oxymetholone developmental 434-07-1 01-May-97
Oxytetracycline (internal use) developmental 79-57-2 01-Jan-91
Oxytetracycline hydrochloride (internal use) developmental 2058-46-0 01-Oct-91
Oxythioquinox (Chinomethionat) cancer 2439-01-2 20-Aug-99
Oxythioquinox (Chinomethionat) developmental 2439-01-2 06-Nov-98
Paclitaxel developmental, female, male 33069-62-4 26-Aug-97
Palygorskite fibers (> 5mm in length) cancer 12174-11-7 28-Dec-99
Panfuran S cancer 794-93-4 01-Jan-88
Paramethadione developmental 115-67-3 01-Jul-90
Penicillamine developmental 52-67-5 01-Jan-91
Pentachlorophenol cancer 87-86-5 01-Jan-90 40
Pentobarbital sodium developmental 57-33-0 01-Jul-90
Pentostatin developmental 53910-25-1 01-Sep-96
Phenacemide developmental 63-98-9 01-Jul-90
Phenacetin cancer 62-44-2 01-Oct-89 300
Phenazopyridine cancer 94-78-0 01-Jan-88 4
Phenazopyridine hydrochloride cancer 136-40-3 01-Jan-88 5
Phenesterin cancer 3546-10-9 01-Jul-89 0.005
Phenobarbital cancer 50-06-6 01-Jan-90 2
Phenolphthalein cancer 77-09-8 15-May-98
Phenoxybenzamine cancer 59-96-1 01-Apr-88 0.2
Phenoxybenzamine hydrochloride cancer 63-92-3 01-Apr-88 0.3
Phenprocoumon developmental 435-97-2 01-Oct-92
o-Phenylenediamine and its salts cancer 95-54-5 15-May-98
o-Phenylenediamine 26
o-Phenylenediamine dihydochloride 44
Phenyl glycidyl ether cancer 122-60-1 01-Oct-90 5
Phenyl glycidyl ether male 122-60-1 07-Aug-09
Phenylhydrazine and its salts cancer --- 01-Jul-92
Phenylhydrazine 1
Phenylhydrazine hydrochloride 1.4
o-Phenylphenate, sodium cancer 132-27-4 01-Jan-90 200
o-Phenylphenol cancer 90-43-7 04-Aug-00
Phenylphosphine developmental 638-21-1 07-Aug-09
PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) cancer 105650-23-5 01-Oct-94
Pimozide developmental, female 2062-78-4 20-Aug-99
Pipobroman developmental 54-91-1 01-Jul-90
Pirimicarb cancer 23103-98-2 01-Jul-08
Plicamycin developmental 18378-89-7 01-Apr-90
Polybrominated biphenyls cancer --- 01-Jan-88 0.02
Polybrominated biphenyls developmental --- 01-Oct-94
Polychlorinated biphenyls cancer --- 01-Oct-89 0.09
Polychlorinated biphenyls developmental --- 01-Jan-91
Polychlorinated biphenyls (containing 60 or more percent percent chlorine by molecular weight) cancer --- 01-Jan-88
Polychlorinated dibenzo-p-dioxins cancer --- 01-Oct-92
Polychlorinated dibenzofurans cancer --- 01-Oct-92
Polygeenan cancer 53973-98-1 01-Jan-88 1200
Ponceau MX cancer 3761-53-3 01-Apr-88 200
Ponceau 3R cancer 3564-09-8 01-Apr-88 40
Potassium bromate cancer 7758-01-2 01-Jan-90 1
Potassium dimethyldithiocarbamate developmental 128-03-0 30-Mar-99 720
Pravastatin sodium developmental 81131-70-6 03-Mar-00
Prednisolone sodium phosphate developmental 125-02-0 20-Aug-99
Primidone cancer 125-33-7 20-Aug-99
Procarbazine cancer 671-16-9 01-Jan-88 0.05
Procarbazine hydrochloride cancer 366-70-1 01-Jan-88 0.06
Procarbazine hydrochloride developmental 366-70-1 01-Jul-90
Procymidone cancer 32809-16-8 01-Oct-94
Progesterone cancer 57-83-0 01-Jan-88
Pronamide cancer 23950-58-5 01-May-96
Propachlor cancer 1918-16-7 27-Feb-01
1,3-Propane sultone cancer 1120-71-4 01-Jan-88 0.3
Propargite cancer 2312-35-8 01-Oct-94
Propargite developmental 2312-35-8 15-Jun-99
beta-Propiolactone cancer 57-57-8 01-Jan-88 0.05
Propoxur cancer 114-26-1 11-Aug-06
Propylene glycol mono-t-butyl ether cancer 57018-52-7 11-Jun-04
Propylene oxide cancer 75-56-9 01-Oct-88
Propylthiouracil cancer 51-52-5 01-Jan-88 0.7
Propylthiouracil developmental 51-52-5 01-Jul-90
Pyrimethamine developmental 58-14-0 29-Jan-99
Pyridine cancer 110-86-1 17-May-02
Quazepam developmental 36735-22-5 26-Aug-97
Quinoline and its strong acid salts cancer --- 24-Oct-97
Quizalofop-ethyl male 76578-14-8 24-Dec-99 590
Radionuclides cancer --- 01-Jul-89
Reserpine cancer 50-55-5 01-Oct-89 0.06
Residual (heavy) fuel oils cancer --- 01-Oct-90
Resmethrin cancer 10453-86-8 01-Jul-08
Resmethrin developmental 10453-86-8 06-Nov-98
Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) developmental --- 01-Jul-89
Ribavirin developmental 36791-04-5 01-Apr-90
Ribavirin male 36791-04-5 27-Feb-01
Riddelliine cancer 23246-96-0 03-Dec-04
Rifampin developmental, female 13292-46-1 27-Feb-01
Saccharin Delisted April 6, 2001 cancer 81-07-2 01-Oct-89
Saccharin, sodium Delisted January 17, 2003 cancer 128-44-9 01-Jan-88
Safrole cancer 94-59-7 01-Jan-88 3
Secobarbital sodium developmental 309-43-3 01-Oct-92
Selenium sulfide cancer 7446-34-6 01-Oct-89
Sermorelin acetate developmental --- 20-Aug-99
Shale-oils cancer 68308-34-9 01-Apr-90
Silica, crystalline (airborne particles of respirable size) cancer --- 01-Oct-88
Sodium dimethyldithiocarbamate developmental 128-04-1 30-Mar-99 23 (oral) 58 (oral) as a 40% pesticidal formulation
Sodium fluoroacetate male 62-74-8 06-Nov-98
Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) cancer --- 27-Feb-87
Spironolactone cancer 52-01-7 01-May-97
Stanozolol cancer 10418-03-8 01-May-97
Sterigmatocystin cancer 10048-13-2 01-Apr-88 0.02
Streptomycin sulfate developmental 3810-74-0 01-Jan-91
Streptozocin (streptozotocin) developmental, female, male 18883-66-4 20-Aug-99
Streptozotocin (streptozocin) cancer 18883-66-4 01-Jan-88 0.006
Strong inorganic acid mists containing sulfuric acid cancer --- 14-Mar-03
Styrene oxide cancer 96-09-3 01-Oct-88 4
Sulfallate cancer 95-06-7 01-Jan-88 4
Sulfasalazine (salicylazosulfapyridine) cancer 599-79-1 15-May-98
Sulfasalazine (salicylazosulfapyridine) male 599-79-1 29-Jan-99
Sulindac developmental, female 38194-50-2 29-Jan-99
Talc containing asbestiform fibers cancer --- 01-Apr-90
Tamoxifen and its salts cancer 10540-29-1 01-Sep-96
Tamoxifen citrate developmental 54965-24-1 01-Jul-90
Temazepam developmental 846-50-4 01-Apr-90
Teniposide developmental 29767-20-2 01-Sep-96
Terbacil developmental 5902-51-2 18-May-99
Terrazole cancer 2593-15-9 01-Oct-94
Testosterone and its esters cancer 58-22-0 01-Apr-88
Testosterone cypionate developmental 58-20-8 01-Oct-91
Testosterone enanthate developmental 315-37-7 01-Apr-90
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) cancer 1746-01-6 01-Jan-88 0.000005
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) developmental 1746-01-6 01-Apr-91
1,1,2,2-Tetrachloroethane cancer 79-34-5 01-Jul-90 3
Tetrachloroethylene (Perchloroethylene) cancer 127-18-4 01-Apr-88 14
p-a,a,a-Tetrachlorotoluene cancer 5216-25-1 01-Jan-90
Tetracycline (internal use) developmental 60-54-8 01-Oct-91
Tetracyclines (internal use) developmental --- 01-Oct-92
Tetracycline hydrochloride (internal use) developmental 64-75-5 01-Jan-91
Tetrafluoroethylene cancer 116-14-3 01-May-97
Tetranitromethane cancer 509-14-8 01-Jul-90 0.059
Thalidomide developmental 50-35-1 01-Jul-87
Thioacetamide cancer 62-55-5 01-Jan-88 0.1
4,4'-Thiodianiline cancer 139-65-1 01-Apr-88 0.05
Thiodicarb cancer 59669-26-0 20-Aug-99
Thioguanine developmental 154-42-7 01-Jul-90
Thiophanate methyl female, male 23564-05-8 18-May-99 600 (oral)
Thiouracil cancer 141-90-2 11-Jun-04
Thiourea cancer 62-56-6 01-Jan-88 10
Thorium dioxide cancer 1314-20-1 27-Feb-87
Tobacco, oral use of smokeless products cancer --- 01-Apr-88
Tobacco smoke cancer --- 01-Apr-88
Tobacco smoke (primary) developmental, female, male --- 01-Apr-88
Tobramycin sulfate developmental 49842-07-1 01-Jul-90
Toluene developmental 108-88-3 01-Jan-91 7000b
Toluene female 108-88-3 07-Aug-09
Toluene diisocyanate cancer 26471-62-5 01-Oct-89 20
o-Toluidine cancer 95-53-4 01-Jan-88 4
o-Toluidine hydrochloride cancer 636-21-5 01-Jan-88 5
para-Toluidine Delisted October 29, 1999 cancer 106-49-0 01-Jan-90
Toxaphene (Polychlorinated camphenes) cancer 8001-35-2 01-Jan-88 0.6
Toxins derived from Fusarium moniliforme (Fusarium verticillioides) cancer --- 07-Aug-09
Treosulfan cancer 299-75-2 27-Feb-87
Triadimefon developmental, female, male 43121-43-3 30-Mar-99
Triazolam developmental 28911-01-5 01-Apr-90
Tributyltin methacrylate developmental 2155-70-6 01-Dec-99
Trichlormethine (Trimustine hydrochloride) cancer 817-09-4 01-Jan-92
Trichloroethylene cancer 79-01-6 01-Apr-88 50 (oral) 80 (inhalation)
2,4,6-Trichlorophenol cancer 88-06-2 01-Jan-88 10
1,2,3-Trichloropropane cancer 96-18-4 01-Oct-92
Trientine hydrochloride developmental 38260-01-4 27-Feb-01
Triforine developmental 26644-46-2 18-Jun-99
1,3,5-Triglycidyl-s-triazinetrione male 2451-62-9 07-Aug-09
Trilostane developmental 13647-35-3 01-Apr-90
Trimethadione developmental 127-48-0 01-Jan-91
2,4,5-Trimethylaniline and its strong acid salts cancer --- 24-Oct-97
Trimethyl phosphate cancer 512-56-1 01-May-96 24
Trimetrexate glucuronate developmental 82952-64-5 26-Aug-97
2,4.6-Trinitrotoluene (TNT) cancer 118-96-7 19-Dec-08
Triphenyltin hydroxide cancer 76-87-9 01-Jul-92
Triphenyltin hydroxide developmental 76-87-9 18-Mar-02
Tris(aziridinyl)-p-benzoquinone (Triaziquone) Delisted December 8, 2006 cancer 68-76-8 01-Oct-89
Tris(1-aziridinyl)phosphine sulfide (Thiotepa) cancer 52-24-4 01-Jan-88 0.06
Tris(2-chloroethyl) phosphate cancer 115-96-8 01-Apr-92
Tris(2,3-dibromopropyl)phosphate cancer 126-72-7 01-Jan-88 0.3
Trp-P-1 (Tryptophan-P-1) cancer 62450-06-0 01-Apr-88 0.03
Trp-P-2 (Tryptophan-P-2) cancer 62450-07-1 01-Apr-88 0.2
Trypan blue (commercial grade) cancer 72-57-1 01-Oct-89
Unleaded gasoline (wholly vaporized) cancer --- 01-Apr-88
Uracil mustard cancer 66-75-1 01-Apr-88
Uracil mustard developmental, female, male 66-75-1 01-Jan-92
Urethane (Ethyl carbamate) cancer 51-79-6 01-Jan-88 0.7
Urethane (Ethyl carbamate) developmental 51-79-6 01-Oct-94
Urofollitropin developmental 97048-13-0 01-Apr-90
Valproate (Valproic acid) developmental 99-66-1 01-Jul-87
Vanadium pentoxide (orthorhombic crystalline form) cancer 1314-62-1 11-Feb-05
Vinblastine sulfate developmental 143-67-9 01-Jul-90
Vinclozolin cancer 50471-44-8 20-Aug-99
Vinclozolin developmental 50471-44-8 15-May-98
Vincristine sulfate developmental 2068-78-2 01-Jul-90
Vinyl bromide cancer 593-60-2 01-Oct-88
Vinyl chloride cancer 75-01-4 27-Feb-87 3
4-Vinylcyclohexene cancer 100-40-3 01-May-96
4-Vinylcyclohexene female, male 100-40--3 07-Aug-09
4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) cancer 106-87-6 01-Jul-90
Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide) female, male 106-87-6 01-Aug-08
Vinyl fluoride cancer 75-02-5 01-May-97
Vinyl trichloride (1,1,2-Trichloroethane) cancer 79-00-5 01-Oct-90 10
Warfarin developmental 81-81-2 01-Jul-87
Wood dust cancer --- 18-Dec-09
2,6-Xylidine (2,6-Dimethylaniline) cancer 87-62-7 01-Jan-91 110
Zalcitabine cancer 7481-89-2 07-Aug-09
Zidovudine (AZT) cancer 30516-87-1 18-Dec-09
Zileuton cancer, developmental, female 111406-87-2 22-Dec-00
Zineb Delisted October 29, 1999 cancer 12122-67-7 01-Jan-90
a Where a source or product results in exposures by multiple routes, the total exposure must be considered. For example, the MADL for benzene is exceeded when the absorbed dose exceeds 24 µg/day. If only inhalation and oral exposure occurs, the benzene MADL is exceeded when: (oral dose ÷ 24 µg/day) + (inhalation dose ÷ 49 µg/day) > 1.0.
b Level represents absorbed dose (rounded from 6,525 µg/day ). Since 100% of ingested toluene is absorbed, oral dose is equivalent to administered dose. It is assumed that roughly 50% of the dose administered by the inhalation route is absorbed. Therefore the MADL for inhaled toluene is 13,000 µg/day (rounded from 13,050 µg/day ), corresponding to an absorbed dose of 6,525 µg/day.